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KMID : 0361620030380060641
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Journal of the Korean Orthopaedic Association
2003 Volume.38 No. 6 p.641 ~ p.645
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Expression of Inducible Nitric Oxide Synthase(iNOS, NOS2) in Osteosarcoma Correlates with Prognosis
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Yang Seung-Han
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Abstract
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Purpose : This study was perfomed to investigate the expression pattern of inducib;e nitric oxide synthase (iNOS) in osteosarc~na and to determir~ whether its expression correlates with metastatic potential and prognosis.
Materials acrd Meltlods : Patholog~.tisstJes obtained from 48 patients with primary osteosarcoma were examined immurlohistochemically. Stained tissues were categorized into three groups (neoatiye, mild, strong). accordng to expressiol intensit)r, and matched with clinical-data Results were arrdtysed statistically. .´
Results : iNOS was expressed in.18 of 48 s~rrlples (38~). ~-9 the iNOS positive cases, mild expression was observed in 9 patients (18%). There was statistically significant correlation between mild iNOS expression and metastasis (p=0.019). By multivariate analysis mild iNOS expression turned out to be a signficant prognostic factor for reduced survival (Risk ratio 4.399, 95~ CI 1.694-11.421: p=0.02). Cor>cttrsiorl: Mild expression of iNOS was signrficantly related to metastasis in osteosarcoma and can be considered a signficant prognostic factor.
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KEYWORD
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